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IOPROMIDE
DIR Classification
Classification:Most-DIR concern
Severity Score:4
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- BOXED WARNING
- Inadvertent intrathecal administration may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema. [See Contraindications (4).]
- CONTRAINDICATIONS
- Do not administer ULTRAVIST Injection intrathecally. Inadvertent intrathecal administration may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema.
- Preparatory dehydration (for example, prolonged fasting and the administration of a laxative) before ULTRAVIST Injection is contraindicated in pediatric patients because of risk of acute renal failure.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
Rhabdomyolysis
10
42902
Other ADRs
7747
14109532
Odds Ratio = 0.425
Drug Property Information
ATC Code(s):
- V08AB05 - iopromide
- V08AB - "Watersoluble, nephrotropic, low osmolar X-ray contrast media"
- V08A - "X-RAY CONTRAST MEDIA, IODINATED"
- V08 - CONTRAST MEDIA
- V - VARIOUS
Active Ingredient:iopromide
Active Ingredient UNII:712BAC33MZ
Drugbank ID:DB09156
PubChem Compound:3736
CAS Number:73334-07-3
Dosage Form(s):injection
Route(s) Of Administrator:intra-arterial
Daily Dose:
Chemical Structure: 
SMILE Code:
CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I
CN(CC(CO)O)C(=O)C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)NC(=O)COC)I
Reference
COHORT STUDY:
N/AOTHER REFERENCE(S):
N/ADisclaimer:
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