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UROKINASE
DIR Classification
Classification:Less-DIR concern
Severity Score:1
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- WARNINGS
- Cholesterol Embolization
- Cholesterol embolism has been reported rarely in patients treated with all types of thrombolytic agents; the true incidence is unknown. This serious condition, which can be lethal, is also associated with invasive vascular procedures (e.g., cardiac catheterization, angiography, vascular surgery) and/or anticoagulant therapy. Clinical features of cholesterol embolism may include livedo reticularis, “purple toe” syndrome, acute renal failure, gangrenous digits, hypertension, pancreatitis, myocardial infarction, cerebral infarction, spinal cord infarction, retinal artery occlusion, bowel infarction and rhabdomyolysis.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
Rhabdomyolysis
0
42912
Other ADRs
211
14117068
Odds Ratio = N/A
Drug Property Information
ATC Code(s):
- B01AD04 - urokinase
- B01AD - Enzymes
- B01A - ANTITHROMBOTIC AGENTS
- B01 - ANTITHROMBOTIC AGENTS
- B - BLOOD AND BLOOD FORMING ORGANS
Active Ingredient:urokinase
Active Ingredient UNII:83G67E21XI
Drugbank ID:DB00013
PubChem Compound:N/A
CAS Number:9039-53-6
Dosage Form(s):injection, powder, lyophilized, for solution
Route(s) Of Administrator:intravenous
Daily Dose:
- 3MU B01AD04
Chemical Structure: 
SMILE Code:
-
-
Reference
COHORT STUDY:
N/AOTHER REFERENCE(S):
1: Acute ischaemia of the leg following accidental intra-arterial injection of dissolved flunitrazepam tablets.
[Leifert J A,Bossaller L,Uhl M]Vasa.2008 Nov;37(4):374-8. doi: 10.1024/0301-1526.37.4.374. PMID: 19003750
2: Success of thrombolysis as a predictor of outcome in acute thrombosis of popliteal aneurysms.
[Marty Bettina,Wicky Stephan,Ris Hans-Beat,Mueller Xavier,Fischer Adam,Hayoz Daniel,von Segesser Ludwig Karl]J Vasc Surg.2002 Mar;35(3):487-93. PMID: 11877696
3: Increased limb salvage with intraoperative and postoperative ankle level urokinase infusion in acute lower extremity ischemia.
[Wyffels P L,DeBord J R,Marshall J S,Thors G,Marshall W H]J Vasc Surg.1992 May;15(5):771-8; discussion 778-9. PMID: 1578532
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