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IFOSFAMIDE


DIR Classification


Classification:Less-DIR concern
Severity Score:1

Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF

  • ADVERSE REACTIONS
  • Postmarketing Experience
  • MUSCULOSKELETAL AND CONNECTIVE TISSUE DISORDER:
  • Rhabdomyolysis, Osteomalacia, Rickets, Growth retardation, Myalgia, Arthralgia, Pain in extremity, Muscle twitching

Postmarketing Surveillance

Contingency Table:

Current Drug
Other Drugs
Rhabdomyolysis
17
42895
Other ADRs
3125
14114154

Odds Ratio = 1.79

Drug Property Information



ATC Code(s):
  • L01AA06 - ifosfamide
    • L01AA - Nitrogen mustard analogues
    • L01A - ALKYLATING AGENTS
    • L01 - ANTINEOPLASTIC AGENTS
    • L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Active Ingredient:ifosfamide
Active Ingredient UNII:UM20QQM95Y
Drugbank ID:DB01181
PubChem Compound:3690
CAS Number:3778-73-2
Dosage Form(s):injection, powder, for solution
Route(s) Of Administrator:intravenous
Daily Dose:
Chemical Structure:
SMILE Code:
C1CN(P(=O)(OC1)NCCCl)CCCl

Reference

COHORT STUDY:

N/A

OTHER REFERENCE(S):

1: Severe Rhabdomyolysis during Treatment with Trabectedin in Combination with a Herbal Drug in a Patient with Metastatic Synovial Sarcoma: A Case Report.

[Damato Angela,Larocca Mario,Rondini Ermanno,Menga Massimo,Pinto Carmine,Versari Annibale]
Case Rep Oncol.2017 Mar 28;10(1):258-264. doi: 10.1159/000464440. eCollection 2017 Jan-Apr. PMID: 28512407

2: Delayed rhabdomyolysis with paclitaxel, ifosfamide, carboplatin, and etoposide regimen: a case report.

[Sokolova Alexandra,Chan Onyee,Ullah Waqas,Hamdani Auon Abbas,Anwer Faiz]
J Med Case Rep.2017 Apr 11;11(1):100. doi: 10.1186/s13256-017-1272-9. PMID: 28395668

3: Effects of blood purification therapy on a patient with ifosfamide-induced neurotoxicity and acute kidney injury.

[Nishimura Hiroaki,Enokida Hideki,Nagano Satoshi,Yokouchi Masahiro,Hayami Hiroshi,Komiya Setsuro,Nakagawa Masayuki]
J Artif Organs.2014 Mar;17(1):110-3. doi: 10.1007/s10047-013-0733-1. Epub 2013 Oct 4. PMID: 24091438

4: Severe acute rhabdomyolysis induced by multi-agent chemotherapy for alveolar rhabdomyosarcoma in a 15-year-old female: a case report.

[Matsuzaki Hiroshi,Koga Yuhki,Suminoe Aiko,Oba Utako,Takimoto Tomohito,Hara Toshiro]
Case Rep Oncol.2013 Jul 31;6(2):397-402. doi: 10.1159/000354271. eCollection 2013. PMID: 24019778

5: Safety evaluation of trabectedin in treatment of soft-tissue sarcomas.

[Martin-Liberal Juan,Judson Ian]
Expert Opin Drug Saf.2013 Nov;12(6):905-11. doi: 10.1517/14740338.2013.829037. Epub 2013 Aug 12. PMID: 23937190

6: Herbal-drug interaction induced rhabdomyolysis in a liposarcoma patient receiving trabectedin.

[Strippoli Sabino,Lorusso Vito,Albano Anna,Guida Michele]
BMC Complement Altern Med.2013 Jul 30;13:199. doi: 10.1186/1472-6882-13-199. PMID: 23899130

7: Animal models of acute renal failure.

[Singh Amrit Pal,Junemann Anselm,Muthuraman Arunachalam,Jaggi Amteshwar Singh,Singh Nirmal,Grover Kuldeep,Dhawan Ravi]
Pharmacol Rep.2012;64(1):31-44. PMID: 22580518

8: Long-term results of first-line sequential high-dose carboplatin, etoposide and ifosfamide chemotherapy with peripheral blood stem cell support for patients with advanced testicular germ cell tumor.

[Miki Tsuneharu,Mizutani Yoichi,Akaza Hideyuki,Ozono Seiichiro,Tsukamoto Taiji,Terachi Toshiro,Naito Katsusuke,Nonomura Norio,Hara Isao,Yoshida Osamu,Japan Blood Cell Transplantation Study Group for Testicular Germ Cell Tumor]
Int J Urol.2007 Jan;14(1):54-9. PMID: 17199861

9: [Acute renal failure].

[Krych M]
Internist (Berl).2005 Jan;46(1):30-8. PMID: 15580461

10: Safety and efficacy of ET-743: the French experience.

[Brain Etienne G C]
Anticancer Drugs.2002 May;13 Suppl 1:S11-4. PMID: 12173489

11: Diffuse brachial plexopathy after interscalene blockade in a patient receiving cisplatin chemotherapy: the pharmacologic double crush syndrome.

[Hebl J R,Horlocker T T,Pritchard D J]
Anesth Analg.2001 Jan;92(1):249-51. PMID: 11133638

12: Severe rhabdomyolysis as a complication of high-dose chemotherapy in a patient with advanced testicular cancer.

[Hoshi S,Itoh A,Kato S,Suzuki K,Kawamura S,Orikasa S]
Int J Urol.1999 Jan;6(1):56-8. PMID: 10221868

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