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IOPAMIDOL
DIR Classification
Classification:Most-DIR concern
Severity Score:4
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- ADVERSE REACTIONS
- Following coronary and ventricular injections, certain electrocardiographic changes (increased QTc, increased R-R, T-wave amplitude) and certain hemodynamic changes (decreased systolic pressure) occurred less frequently with ISOVUE (lopamidol Injection) than with diatrizoate meglumine and diatrizoate sodium injection; increased LVEDP occurred less frequently after ventricular iopamidol injections.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
Rhabdomyolysis
18
42894
Other ADRs
3907
14113372
Odds Ratio = 1.516
Drug Property Information
ATC Code(s):
- V08AB04 - iopamidol
- V08AB - "Watersoluble, nephrotropic, low osmolar X-ray contrast media"
- V08A - "X-RAY CONTRAST MEDIA, IODINATED"
- V08 - CONTRAST MEDIA
- V - VARIOUS
Active Ingredient:iopamidol
Active Ingredient UNII:JR13W81H44
Drugbank ID:DB08947
PubChem Compound:65492
CAS Number:60166-93-0
Dosage Form(s):injection, solution
Route(s) Of Administrator:intravascular
Daily Dose:
Chemical Structure: 
SMILE Code:
C[C@@H](C(=O)NC1=C(C(=C(C(=C1I)C(=O)NC(CO)CO)I)C(=O)NC(CO)CO)I)O
C[C@@H](C(=O)NC1=C(C(=C(C(=C1I)C(=O)NC(CO)CO)I)C(=O)NC(CO)CO)I)O
Reference
COHORT STUDY:
N/AOTHER REFERENCE(S):
1: Rhabdomyolysis in an HIV-infected patient following coronary angiography: case report and literature review.
[Sbrana Francesco,Coceani Michele,Iapoce Riccardo,Petersen Christina,Rovai Daniele]Int J STD AIDS.2014 May;25(6):452-4. doi: 10.1177/0956462413512809. Epub 2013 Nov 20. PMID: 24256695
2: Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent.
[Longo Dario Livio,Busato Alice,Lanzardo Stefania,Antico Federica,Aime Silvio]Magn Reson Med.2013 Sep;70(3):859-64. doi: 10.1002/mrm.24513. Epub 2012 Oct 11. PMID: 23059893
3: Case report: multisystem failure following intravenous iopamidol.
[Lucas L M,Colley C A,Gordon G H]Clin Radiol.1992 Apr;45(4):276-7. PMID: 1395388
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