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VALSARTAN
DIR Classification
Classification:Less-DIR concern
Severity Score:1
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- ADVERSE REACTIONS
- Post-Marketing Experience
- Rare cases of rhabdomyolysis have been reported in patients receiving angiotensin II receptor blockers.
- Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
Rhabdomyolysis
138
42774
Other ADRs
21438
14095841
Odds Ratio = 2.122
Drug Property Information
ATC Code(s):
- C09DX02 - valsartan
- C09DX -
- C09D - "ANGIOTENSIN II ANTAGONISTS, COMBINATIONS"
- C09 - AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
- C - CARDIOVASCULAR SYSTEM
- C09DB08 - valsartan
- C09DB - Angiotensin II antagonists and calcium channel blockers
- C09D - "ANGIOTENSIN II ANTAGONISTS, COMBINATIONS"
- C09 - AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
- C - CARDIOVASCULAR SYSTEM
- C10BX10 - valsartan
- C10BX - "HMG CoA reductase inhibitors, other combinations"
- C10B - "LIPID MODIFYING AGENTS, COMBINATIONS"
- C10 - LIPID MODIFYING AGENTS
- C - CARDIOVASCULAR SYSTEM
- C09DB01 - valsartan
- C09DB - Angiotensin II antagonists and calcium channel blockers
- C09D - "ANGIOTENSIN II ANTAGONISTS, COMBINATIONS"
- C09 - AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
- C - CARDIOVASCULAR SYSTEM
- C09DX01 - valsartan
- C09DX -
- C09D - "ANGIOTENSIN II ANTAGONISTS, COMBINATIONS"
- C09 - AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
- C - CARDIOVASCULAR SYSTEM
- C09DA03 - valsartan
- C09DA - Angiotensin II antagonists and diuretics
- C09D - "ANGIOTENSIN II ANTAGONISTS, COMBINATIONS"
- C09 - AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
- C - CARDIOVASCULAR SYSTEM
- C09DX04 - valsartan
- C09DX -
- C09D - "ANGIOTENSIN II ANTAGONISTS, COMBINATIONS"
- C09 - AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
- C - CARDIOVASCULAR SYSTEM
- C09CA03 - valsartan
- C09CA - "Angiotensin II antagonists, plain"
- C09C - "ANGIOTENSIN II ANTAGONISTS, PLAIN"
- C09 - AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
- C - CARDIOVASCULAR SYSTEM
Active Ingredient:valsartan
Active Ingredient UNII:80M03YXJ7I
Drugbank ID:DB00177
PubChem Compound:60846
CAS Number:137862-53-4
Dosage Form(s):tablet
Route(s) Of Administrator:oral
Daily Dose:
- 80.0 mg/day C09CA03
Chemical Structure: 
SMILE Code:
CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O
CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O
Reference
COHORT STUDY:
N/AOTHER REFERENCE(S):
1: Rhabdomyolysis After Coadministration of Atorvastatin and Sacubitril/Valsartan (Entresto™) in a 63-Year-Old Woman.
[Faber Eve S,Gavini Madhavi,Ramirez Ronald,Sadovsky Richard]Drug Saf Case Rep.2016 Dec;3(1):14. PMID: 27804100
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