Search for drugs:
Typing the drug name to query
IOVERSOL
DIR Classification
Classification:Most-DIR concern
Severity Score:4
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- BOXED WARNING
- Inadvertent intrathecal administration may cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema. (5.1)
- WARNINGS AND PRECAUTIONS
- Risks Associated with Inadvertent Intrathecal Administration
- Optiray is indicated for intravascular use only [see Dosage and Administration (2.1)]. Inadvertent intrathecal administration can cause death, convulsions, cerebral hemorrhage, coma, paralysis, arachnoiditis, acute renal failure, cardiac arrest, seizures, rhabdomyolysis, hyperthermia, and brain edema.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
Rhabdomyolysis
0
42912
Other ADRs
3802
14113477
Odds Ratio = N/A
Drug Property Information
ATC Code(s):
- V08AB07 - ioversol
- V08AB - "Watersoluble, nephrotropic, low osmolar X-ray contrast media"
- V08A - "X-RAY CONTRAST MEDIA, IODINATED"
- V08 - CONTRAST MEDIA
- V - VARIOUS
Active Ingredient:ioversol
Active Ingredient UNII:N3RIB7X24K
Drugbank ID:DB09134
PubChem Compound:3741
CAS Number:87771-40-2
Dosage Form(s):injection
Route(s) Of Administrator:intra-arterial; intravenous
Daily Dose:
Chemical Structure: 
SMILE Code:
C(CO)N(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)CO
C(CO)N(C1=C(C(=C(C(=C1I)C(=O)NCC(CO)O)I)C(=O)NCC(CO)O)I)C(=O)CO
Reference
COHORT STUDY:
N/AOTHER REFERENCE(S):
N/ADisclaimer:
The content of this database of rhabdomyolysis is intended for educational and scientific research purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment.
The views presented in this website do not necessarily reflect current or future opinion or policy of the US Food and Drug Administration. Any mention of commercial products is for clarification and not intended as endorsement.