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BREXPIPRAZOLE
DIR Classification
Classification:Most-DIR concern
Severity Score:4
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- CLINICAL PHARMACOLOGY
- Pharmacodynamics
- Cardiac Electrophysiology
- At a dose 3 times the MRHD for the treatment of schizophrenia and 4 times the MRHD for adjunctive therapy to antidepressants for the treatment of MDD, REXULTI does not prolong the QTc interval to any clinically relevant extent.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
Rhabdomyolysis
3
42909
Other ADRs
2615
14114664
Odds Ratio = 0.378
Drug Property Information
ATC Code(s):
- N05AX16 - brexpiprazole
- N05AX - Other antipsychotics
- N05A - ANTIPSYCHOTICS
- N05 - PSYCHOLEPTICS
- N - NERVOUS SYSTEM
Active Ingredient:brexpiprazole
Active Ingredient UNII:2J3YBM1K8C
Drugbank ID:DB09128
PubChem Compound:11978813
CAS Number:913611-97-9
Dosage Form(s):tablet
Route(s) Of Administrator:oral
Daily Dose:
- 3.0 mg/day N05AX16
Chemical Structure: 
SMILE Code:
C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4
C1CN(CCN1CCCCOC2=CC3=C(C=C2)C=CC(=O)N3)C4=C5C=CSC5=CC=C4
Reference
COHORT STUDY:
N/AOTHER REFERENCE(S):
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