DIRA 1.0: Atlas of Drug-induced Rhabdomyolysis

METHAMPHETAMINE HYDROCHLORIDE

Classification:Moderate-DIR concern

Severity Score:2

OVERDOSAGE
Manifestations of acute overdosage with methamphetamine include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic states, hyperpyrexia, and rhabdomyolysis. Fatigue and depression usually follow the central stimulation. Cardiovascular effects include arrhythmias, hypertension or hypotension, and circulatory collapse. Gastrointestinal symptoms include nausea, vomiting, diarrhea, and abdominal cramps. Fatal poisoning usually terminates in convulsions and coma.
Consult with a Certified Poison Control Center regarding treatment for up to date guidance and advice. Management of acute methamphetamine intoxication is largely symptomatic and includes gastric evacuation, administration of activated charcoal, and sedation. Experience with hemodialysis or peritoneal dialysis is inadequate to permit recommendations in this regard.
Acidification of urine increases methamphetamine excretion, but is believed to increase risk of acute renal failure if myoglobinuria is present. Intravenous phentolamine (Regitine) has been suggested for possible acute, severe hypertension, if this complicates methamphetamine overdosage. Usually a gradual drop in blood pressure will result when sufficient sedation has been achieved. Chlorpromazine has been reported to be useful in decreasing CNS stimulation and sympathomimetic effects.

Current Drug

Other Drugs

Rhabdomyolysis

42899

Other ADRs

719

14116560

Odds Ratio = 5.95

ATC Code(s):

Active Ingredient:methamphetamine hydrochloride

Active Ingredient UNII:997F43Z9CV

Drugbank ID:DB01577

PubChem Compound:10836

CAS Number:537-46-2

Dosage Form(s):tablet

Route(s) Of Administrator:oral

Daily Dose:

Chemical Structure:

SMILE Code:
C[C@@H](CC1=CC=CC=C1)NC

N/A

N/A