DIQTA 1.0: Drug-Induced QT Prolongation Atlas

PERPHENAZINE

DIR Classification Postmarketing Surveillance Drug Property Information Reference

DIR Classification

Classification:Most-DIQT concern

Severity Score:4.0

Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF

OVERDOSAGE
In the event of overdosage, emergency treatment should be started immediately. Consultation with a poison center should be considered. All patients suspected of having taken an overdose should be hospitalized as soon as possible.
[Manifestations]
The toxic effects of perphenazine are typically mild to moderate with death occurring in cases involving a large overdose. Overdosage of perphenazine primarily involves the extrapyramidal mechanism and produces the same side effects described under ADVERSE REACTIONS, but to a more marked degree. It is usually evidenced by stupor or coma; children may have convulsive seizures. Signs of arousal may not occur for 48 hours. The primary effects of medical concern are cardiac in origin including tachycardia, prolongation of the QRS or QTc intervals, atrioventricular block, torsade de pointes, ventricular dysrhythmia, hypotension or cardiac arrest, which indicate serious poisoning. Deaths by deliberate or accidental overdosage have occurred with this class of drugs.

Postmarketing Surveillance

Contingency Table:

Current Drug

Other Drugs

QT Prolongation

24091

Other ADRs

832

38380755

Odds Ratio = 1.915

Drug Property Information

ATC Code(s):

N05AB03 - perphenazine

N05AB - Phenothiazines with piperazine structure
N05A - ANTIPSYCHOTICS
N05 - PSYCHOLEPTICS
N - NERVOUS SYSTEM

Active Ingredient:PERPHENAZINE

Active Ingredient UNII:FTA7XXY4EZ

Drugbank ID:DB00850

PubChem Compound:4748

CTD ID:D010546

PharmGKB:PA450882

CAS Number:58-39-9

Dosage Form(s):tablet, film coated

Route(s) Of Administrator:oral

Daily Dose:

30.0 mg/day N05AB03

Chemical Structure:

SMILE Code:
OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1

Reference

1: Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis.

[Weibel Stephanie,Rücker Gerta,Eberhart Leopold Hj,Pace Nathan L,Hartl Hannah M,Jordan Olivia L,Mayer Debora,Riemer Manuel,Schaefer Maximilian S,Raj Diana,Backhaus Insa,Helf Antonia,Schlesinger Tobias,Kienbaum Peter,Kranke Peter]
Cochrane Database Syst Rev,2020 Oct 19;10:CD012859. PMID: 33075160

2: Antipsychotics and the Risks of Sudden Cardiac Death and All-Cause Death: Cohort Studies in Medicaid and Dually-Eligible Medicaid-Medicare Beneficiaries of Five States.

[Leonard Charles E,Freeman Cristin P,Newcomb Craig W,Bilker Warren B,Kimmel Stephen E,Strom Brian L,Hennessy Sean]
J Clin Exp Cardiolog,2013;Suppl 10(6):1-9. PMID: 24027655

3: Antipsychotic drugs and QT prolongation.

[Stöllberger Claudia,Huber Johannes O,Finsterer Josef]
Int Clin Psychopharmacol,2005 Sep;20(5):243-51. PMID: 16096514

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