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TELOTRISTAT ETHYL
DIR Classification
Classification:Ambiguous
Severity Score:1.0
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- CLINICAL PHARMACOLOGY
- Pharmacodynamics
- Cardiac Electrophysiology
- At a dose 6 times the recommended dose of 250 mg, Xermelo does not prolong the QT interval to any clinically relevant extent.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
QT Prolongation
1
24091
Other ADRs
12246
38369341
Odds Ratio = 0.131
Drug Property Information
ATC Code(s):
- A16AX15 - telotristat ethyl
- A16AX1 -
- A16AX - Various alimentary tract and metabolism products
- A16A - OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
- A16 - OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
- A - ALIMENTARY TRACT AND METABOLISM
Active Ingredient:telotristat ethyl
Active Ingredient UNII:8G388563M7
Drugbank ID:DB12095
PubChem Compound:25025298
CTD ID:C000621725
CAS Number:1033805-22-9
Dosage Form(s):tablet
Route(s) Of Administrator:oral
Daily Dose:
- 750.0 mg/day A16AX15
Chemical Structure: 
SMILE Code:
CCOC(=O)[C@@H](N)CC1=CC=C(C=C1)C1=NC(N)=NC(O[C@H](C2=CC=C(Cl)C=C2N2C=CC(C)=N2)C(F)(F)F)=C1
CCOC(=O)[C@@H](N)CC1=CC=C(C=C1)C1=NC(N)=NC(O[C@H](C2=CC=C(Cl)C=C2N2C=CC(C)=N2)C(F)(F)F)=C1
Reference
N/A
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The content of this database of QT prolongation is intended for educational and scientific research purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment.
Any mention of commercial products is for clarification and not intended as endorsement.