1: Incidence of Corrected QT Prolongation With Concomitant Methadone and Atypical Antipsychotics in Critically Ill Children.

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J Pediatr Pharmacol Ther,2021;26(3):271-276. PMID: 33833629

2: Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age.

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J Psychopharmacol,2021 Mar 28;2698811211003477. PMID: 33779379

3: Pharmacodynamic Drug-Drug interactions of QT-prolonging drugs in hospitalized psychiatric patients.

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J Neural Transm (Vienna),2021 Feb;128(2):243-252. PMID: 33417009

4: Drug-drug interactions between COVID-19 treatments and antipsychotics drugs: integrated evidence from 4 databases and a systematic review.

[Plasencia-García Beatriz Oda,Rodríguez-Menéndez Gonzalo,Rico-Rangel María Isabel,Rubio-García Ana,Torelló-Iserte Jaime,Crespo-Facorro Benedicto]
Psychopharmacology (Berl),2021 Feb;238(2):329-340. PMID: 33410987

5: Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs.

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J Pharmacol Sci,2020 Aug;143(4):330-332. PMID: 32499094

6: Improving prediction of torsadogenic risk in the CiPA in silico model by appropriately accounting for clinical exposure.

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J Pharmacol Toxicol Methods,Jan-Feb 2020;101:106654. PMID: 31730936

7: Coprescription of QT interval-prolonging antipsychotics with potentially interacting medications in Thailand.

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Ther Adv Drug Saf,2019 Jun 13;10:2042098619854886. PMID: 31223470

8: Maximizing response to first-line antipsychotics in schizophrenia: a review focused on finding from meta-analysis.

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Psychopharmacology (Berl),2019 Feb;236(2):545-559. PMID: 30506237

9: Late presentation of Torsades de Pointes related to fluoxetine following a multiple drug overdose.

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J Intensive Care,2018 Sep 10;6:59. PMID: 30214811

10: Antipsychotics for treatment of delirium in hospitalised non-ICU patients.

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Cochrane Database Syst Rev,2018 Jun 18;6(6):CD005594. PMID: 29920656

11: Effects of atypical antipsychotic drugs on QT interval in patients with mental disorders.

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Ann Transl Med,2018 Apr;6(8):147. PMID: 29862236

12: QTc prolongation in short-term treatment of schizophrenia patients: effects of different antipsychotics and genetic factors.

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Eur Arch Psychiatry Clin Neurosci,2018 Jun;268(4):383-390. PMID: 29429138

13: {'sub': 'max', '#text': 'Validation and Clinical Utility of the hERG IC50:C Ratio to Determine the Risk of Drug-Induced Torsades de Pointes: A Meta-Analysis.'}

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Pharmacotherapy,2018 Mar;38(3):341-348. PMID: 29380488

14: Two cases of life-threatening arrhythmia induced by risperidone: evaluation of risperidone and 9-hydroxy-risperidone concentrations.

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Acute Med Surg,2017 Apr 24;4(3):341-343. PMID: 29123887

15: Prevalence of QT interval prolonging drug-drug interactions (QT-DDIs) in psychiatry wards of tertiary care hospitals in Pakistan: a multicenter cross-sectional study.

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Int J Clin Pharm,2017 Dec;39(6):1256-1264. PMID: 28895028

16: Influence of different second generation antipsychotics on the QTc interval: A pragmatic study.

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World J Psychiatry,2016 Dec 22;6(4):442-448. PMID: 28078208

17: Psychosis After Switch in Opioid Maintenance Agonist and Risperidone-Induced Pisa Syndrome: Two Critical Incidents in Dual Diagnosis Treatment.

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J Dual Diagn,Apr-Jun 2017;13(2):157-165. PMID: 27935442

18: Severe proarrhythmic potential of risperidone compared to quetiapine in an experimental whole-heart model of proarrhythmia.

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Naunyn Schmiedebergs Arch Pharmacol,2016 Oct;389(10):1073-80. PMID: 27405774

19: In vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model.

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J Pharmacol Sci,2016 Sep;132(1):48-54. PMID: 27262905

20: Lurasidone: an antipsychotic with antidepressant effects in bipolar depression?

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Australas Psychiatry,2016 Jun;24(3):289-91. PMID: 27036122

21: Diagnosis and Management of Delirium in Critically Ill Infants: Case Report and Review.

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Pediatrics,2016 Mar;137(3):e20151940. PMID: 26908691

22: Absence of Change in Corrected QT Interval in Children and Adolescents Receiving Antipsychotic Treatment: A 12 Month Study.

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J Child Adolesc Psychopharmacol,2016 Jun;26(5):449-57. PMID: 26779966

23: The Contribution of National Spontaneous Reporting Systems to Detect Signals of Torsadogenicity: Issues Emerging from the ARITMO Project.

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Drug Saf,2016 Jan;39(1):59-68. PMID: 26446144

24: Antipsychotic Polypharmacy and Corrected QT Interval: A Systematic Review.

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Can J Psychiatry,2015 May;60(5):215-22. PMID: 26174525

25: Implications of atypical antipsychotic prescribing in the intensive care unit.

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J Crit Care,2015 Aug;30(4):814-8. PMID: 25887805

26: Prolonged QT Risk Assessment in Antipsychotic Overdose Using the QT Nomogram.

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Ann Emerg Med,2015 Aug;66(2):154-64. PMID: 25639523

27: Antipsychotics-associated serious adverse events in children: an analysis of the FAERS database.

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Int J Med Sci,2015 Jan 5;12(2):135-40. PMID: 25589889

28: Corrected QT changes during antipsychotic treatment of children and adolescents: a systematic review and meta-analysis of clinical trials.

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J Am Acad Child Adolesc Psychiatry,2015 Jan;54(1):25-36. PMID: 25524787

29: Blonanserin ameliorated the tendency toward QTc prolongation associated with risperidone in a patient with schizophrenia.

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J Clin Psychopharmacol,2015 Feb;35(1):101-2. PMID: 25502488

30: Olanzapine induced Q-Tc shortening.

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Ther Adv Psychopharmacol,2014 Dec;4(6):240-6. PMID: 25489475

31: A Comparative Study between Olanzapine and Risperidone Regarding Drug-Induced Electrocardiographic Changes.

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Cardiovasc Psychiatry Neurol,2014;2014:637016. PMID: 25276418

32: Management of psychosis and agitation in medical-surgical patients who have or are at risk for prolonged QT interval.

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J Psychiatr Pract,2014 Sep;20(5):338-44. PMID: 25226194

33: Aging effects on QT interval: Implications for cardiac safety of antipsychotic drugs.

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J Geriatr Cardiol,2014 Mar;11(1):20-5. PMID: 24748877

34: Cardiometabolic risks of blonanserin and perospirone in the management of schizophrenia: a systematic review and meta-analysis of randomized controlled trials.

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PLoS One,2014 Feb 4;9(2):e88049. PMID: 24505373

35: A case-based approach to evaluating azithromycin use and cardiovascular risks.

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Consult Pharm,2014 Jan;29(1):47-52. PMID: 24413014

36: Changes in PR and QTc intervals after switching from olanzapine to risperidone in patients with stable schizophrenia.

[Suzuki Yutaro,Sugai Takuro,Ono Shin,Sawamura Kazushi,Fukui Naoki,Watanabe Junzo,Tsuneyama Nobuto,Saito Mami,Someya Toshiyuki]
Psychiatry Clin Neurosci,2014 May;68(5):353-6. PMID: 24405493

37: Torsadogenic risk of antipsychotics: combining adverse event reports with drug utilization data across Europe.

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PLoS One,2013 Nov 20;8(11):e81208. PMID: 24278396

38: Quetiapine versus other atypical antipsychotics for schizophrenia.

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Cochrane Database Syst Rev,2013 Nov 18;(11):CD006625. PMID: 24249315

39: ECG parameters in children and adolescents treated with aripiprazole and risperidone.

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Prog Neuropsychopharmacol Biol Psychiatry,2014 Jun 3;51:23-7. PMID: 24211841

40: Safety profile of iloperidone in the treatment of schizophrenia.

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Expert Opin Drug Saf,2014 Feb;13(2):241-6. PMID: 24206391

41: Antipsychotics and the Risks of Sudden Cardiac Death and All-Cause Death: Cohort Studies in Medicaid and Dually-Eligible Medicaid-Medicare Beneficiaries of Five States.

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J Clin Exp Cardiolog,2013;Suppl 10(6):1-9. PMID: 24027655

42: Risperidone, QTc interval prolongation, and torsade de pointes: a systematic review of case reports.

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Psychopharmacology (Berl),2013 Aug;228(4):515-24. PMID: 23812796

43: Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis.

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Lancet,2013 Sep 14;382(9896):951-62. PMID: 23810019

44: Risk of cardiovascular morbidity with risperidone or paliperidone treatment: analysis of 64 randomized, double-blind trials.

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J Clin Psychopharmacol,2013 Apr;33(2):157-61. PMID: 23422378

45: Selective acquired long QT syndrome (saLQTS) upon risperidone treatment.

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BMC Psychiatry,2012 Dec 5;12:220. PMID: 23216910

46: Changes in QT interval after switching to quetiapine in Japanese patients with schizophrenia.

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Hum Psychopharmacol,2013 Jan;28(1):94-6. PMID: 23161621

47: Risperidone and corrected QT-interval prolongation in surface electrocardiogram.

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Pak J Biol Sci,2012 May 15;15(10):496-500. PMID: 24187905

48: Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.

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J Cardiovasc Pharmacol,2012 Aug;60(2):165-71. PMID: 22561361

49: Increased risk of antipsychotic-related QT prolongation during nighttime: a 24-hour holter electrocardiogram recording study.

[Watanabe Junzo,Suzuki Yutaro,Fukui Naoki,Ono Shin,Sugai Takuro,Tsuneyama Nobuto,Someya Toshiyuki]
J Clin Psychopharmacol,2012 Feb;32(1):18-22. PMID: 22198445

50: Lurasidone: a new treatment option for schizophrenia.

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Drugs Today (Barc),2011 Nov;47(11):807-16. PMID: 22146224

51: QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.

[Suzuki Yutaro,Fukui Naoki,Watanabe Junzo,Ono Shin,Sugai Takuro,Tsuneyama Nobuto,Saito Mami,Inoue Yoshimasa,Someya Toshiyuki]
Hum Psychopharmacol,2012 Jan;27(1):39-42. PMID: 22144033

52: Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics.

[Yang Fu De,Wang Xiang Qun,Liu Xiu Ping,Zhao Ke Xin,Fu Wei Hong,Hao Xue Ru,Zhang Xing Li,Huang Guo Shu,Qu Sheng Cai,Bai Jing Shen,Huang Xu Feng,Kosten Thomas R,Zhang Xiang Yang]
Psychopharmacology (Berl),2011 Jul;216(1):9-16. PMID: 21301815

53: Aripiprazole as a viable alternative for treating delusions of parasitosis.

[Ladizinski Barry,Busse Kristine L,Bhutani Tina,Koo John Y M]
J Drugs Dermatol,2010 Dec;9(12):1531-2. PMID: 21120263

54: Iloperidone for the treatment of schizophrenia.

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Drugs Today (Barc),2010 Aug;46(8):567-79. PMID: 20830317

55: Risperidone-induced QT prolongation following overdose correlates with serum drug concentration and resolves rapidly with no evidence of altered pharmacokinetics.

[Pollak P Timothy,Verjee Zulfikaral H,Lyon Andrew W]
J Clin Pharmacol,2011 Jul;51(7):1112-5. PMID: 20663990

56: QT alterations in psychopharmacology: proven candidates and suspects.

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Curr Drug Saf,2010 Jan;5(1):97-104. PMID: 20210726

57: Quetiapine versus other atypical antipsychotics for schizophrenia.

[Komossa Katja,Rummel-Kluge Christine,Schmid Franziska,Hunger Heike,Schwarz Sandra,Srisurapanont Manit,Kissling Werner,Leucht Stefan]
Cochrane Database Syst Rev,2010 Jan 20;(1):CD006625. PMID: 20091600

58: QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia.

[Ozeki Yuji,Fujii Kumiko,Kurimoto Naoki,Yamada Naoto,Okawa Masako,Aoki Takesuke,Takahashi Jun,Ishida Nobuya,Horie Minoru,Kunugi Hiroshi]
Prog Neuropsychopharmacol Biol Psychiatry,2010 Mar 17;34(2):401-5. PMID: 20079791

59: Aripiprazole versus other atypical antipsychotics for schizophrenia.

[Komossa Katja,Rummel-Kluge Christine,Schmid Franziska,Hunger Heike,Schwarz Sandra,El-Sayeh Hany George G,Kissling Werner,Leucht Stefan]
Cochrane Database Syst Rev,2009 Oct 7;(4):CD006569. PMID: 19821375

60: Update on neuropsychiatric symptoms of dementia: antipsychotic use.

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Geriatrics,2009 May;64(5):10-8. PMID: 19435390

61: Sertindole versus other atypical antipsychotics for schizophrenia.

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Cochrane Database Syst Rev,2009 Apr 15;(2):CD006752. PMID: 19370652

62: QTc prolongation associated with atypical antipsychotic use in the treatment of adolescent-onset anorexia nervosa.

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J Can Acad Child Adolesc Psychiatry,2009 Feb;18(1):60-3. PMID: 19270852

63: [Risperidone use in child and adolescent psychiatric patients].

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Therapie,Sep-Oct 2008;63(5):359-75. PMID: 19154706

64: The role of the New Zealand Intensive Medicines Monitoring Programme in identification of previously unrecognised signals of adverse drug reactions.

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Curr Drug Saf,2006 May;1(2):169-78. PMID: 18690928

65: Treatment of bipolar disorder: the evolving role of atypical antipsychotics.

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Am J Manag Care,2007 Nov;13(7 Suppl):S178-88. PMID: 18041879

66: Torsade de pointes during combined treatment with risperidone and citalopram.

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Pharmacopsychiatry,2007 Nov;40(6):294-5. PMID: 18030657

67: QT interval and dispersion in very young children treated with antipsychotic drugs: a retrospective chart review.

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J Child Adolesc Psychopharmacol,2007 Apr;17(2):187-94. PMID: 17489713

68: Sertindole: new drug. Another "atypical" neuroleptic; QT prolongation.

Prescrire Int,2007 Apr;16(88):59-62. PMID: 17458045

69: Sertindole: efficacy and safety in schizophrenia.

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Expert Opin Pharmacother,2006 Sep;7(13):1825-34. PMID: 16925508

70: [Differences between men and women in side effects of second-generation antipsychotics].

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Nervenarzt,2007 Jan;78(1):45-52. PMID: 16874502

71: Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs.

[Chen Xian,Cordes Jason S,Bradley Jenifer A,Sun Zhuoqian,Zhou Jun]
J Pharmacol Toxicol Methods,Nov-Dec 2006;54(3):261-72. PMID: 16564186

72: A double-blind, controlled study of sertindole versus risperidone in the treatment of moderate-to-severe schizophrenia.

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Int Clin Psychopharmacol,2006 Jan;21(1):49-56. PMID: 16317317

73: Aripiprazole: new drug. Just another neuroleptic.

Prescrire Int,2005 Oct;14(79):163-7. PMID: 16285069

74: Antipsychotic drugs and QT prolongation.

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Int Clin Psychopharmacol,2005 Sep;20(5):243-51. PMID: 16096514

75: QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy.

[Sala Michela,Vicentini Alessandro,Brambilla Paolo,Montomoli Cristina,Jogia Jigar Rs,Caverzasi Eduardo,Bonzano Alberto,Piccinelli Marco,Barale Francesco,De Ferrari Gaetano M]
Ann Gen Psychiatry,2005 Jan 25;4(1):1. PMID: 15845138

76: Risperidone reduces K+ currents in human atrial myocytes and prolongs repolarization in human myocardium.

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Eur J Pharmacol,2004 Aug 23;497(2):215-22. PMID: 15306207

77: Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice.

[Titier Karine,Canal Mireille,Déridet Evelyne,Abouelfath Abdelilah,Gromb Sophie,Molimard Mathieu,Moore Nicholas]
Toxicol Appl Pharmacol,2004 Aug 15;199(1):52-60. PMID: 15289090

78: Using antipsychotic agents in older patients.

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J Clin Psychiatry,2004;65 Suppl 2:5-99; discussion 100-102; quiz 103-4. PMID: 14994733

79: Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.

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Eur J Pharmacol,2004 Feb 20;486(2):209-21. PMID: 14975710

80: A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.

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J Clin Psychopharmacol,2004 Feb;24(1):62-9. PMID: 14709949

81: QTc prolongation: possible association with risperidone and/or haloperidol.

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Psychosomatics,Nov-Dec 2003;44(6):521. PMID: 14597690

82: Risperidone prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current.

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J Cardiovasc Pharmacol,2003 Jun;41(6):934-7. PMID: 12775973

83: Ziprasidone in the management of schizophrenia : the QT interval issue in context.

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CNS Drugs,2003;17(6):423-30. PMID: 12697001

84: Investigation of the potential of clozapine to cause torsade de pointes.

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Adverse Drug React Toxicol Rev,2002;21(4):189-203. PMID: 12503253

85: Aripiprazole.

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CNS Drugs,2002;16(11):779-86; discussion 787-8. PMID: 12383035

86: Electrophysiological effects of risperidone in mammalian cardiac cells.

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87: A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.

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Eur J Pharmacol,2002 Aug 16;450(1):37-41. PMID: 12176106

88: Risperidone prolongs cardiac action potential through reduction of K+ currents in rabbit myocytes.

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Eur J Pharmacol,2002 May 31;444(3):123-32. PMID: 12063072

89: In vivo and in vitro myocardial binding of risperidone and 9-hydroxyrisperidone.

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Toxicol Appl Pharmacol,2002 Apr 15;180(2):145-9. PMID: 11969382

90: Ziprasidone: profile on safety.

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Expert Opin Pharmacother,2001 Oct;2(10):1655-62. PMID: 11825308

91: Tolerability profile of atypical antipsychotics in children and adolescents.

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Paediatr Drugs,2001;3(12):927-42. PMID: 11772153

92: Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death.

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Am J Psychiatry,2001 Nov;158(11):1774-82. PMID: 11691681

93: Olanzapine: new preparation. Keep an eye on this neuroleptic.

Prescrire Int,1999 Oct;8(43):135-8. PMID: 11503836

94: Sudden cardiac death with clozapine and sertraline combination.

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Ann Pharmacother,Jul-Aug 2001;35(7-8):862-6. PMID: 11485134

95: Asymptomatic QTc prolongation associated with quetiapine fumarate overdose in a patient being treated with risperidone.

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Hum Exp Toxicol,2001 Apr;20(4):215-9. PMID: 11393275

96: Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis.

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J Clin Psychiatry,2001 Mar;62(3):191-8. PMID: 11305706

97: Olanzapine. Keep an eye on this neuroleptic.

Can Fam Physician,2000 Feb;46:322-6, 330-6. PMID: 10690489

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