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NALDEMEDINE
DIR Classification
Classification:Ambiguous
Severity Score:1.0
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- CLINICAL PHARMACOLOGY
- Pharmacodynamics
- Effect on Cardiac Repolarization
- At a dose up to 5 times the recommended dose, SYMPROIC does not prolong the QT interval to any clinically relevant extent.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
QT Prolongation
0
24092
Other ADRs
0
38381587
Odds Ratio = N/A
Drug Property Information
ATC Code(s):
- A06AH05 - naldemedine
- A06AH0 -
- A06AH -
- A06A - LAXATIVES
- A06 - LAXATIVES
- A - ALIMENTARY TRACT AND METABOLISM
Active Ingredient:naldemedine tosylate
Active Ingredient UNII:V1N8F1RVVO
Drugbank ID:DB11691
PubChem Compound:54732242
CTD ID:C000620491
CAS Number:916072-89-4
Dosage Form(s):tablet
Route(s) Of Administrator:oral
Daily Dose:
- 0.2 mg/day A06AH05
Chemical Structure: 
SMILE Code:
[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC(C(=O)NC(C)(C)C1=NC(=NO1)C1=CC=CC=C1)=C2O)=CC=C3O
[H][C@@]12OC3=C4C(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]5(O)CC(C(=O)NC(C)(C)C1=NC(=NO1)C1=CC=CC=C1)=C2O)=CC=C3O
Reference
N/A
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The content of this database of QT prolongation is intended for educational and scientific research purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment.
Any mention of commercial products is for clarification and not intended as endorsement.