Search for drugs:
Typing the drug name to query
AMITRIPTYLINE HYDROCHLORIDE
DIR Classification
Classification:Moderate-DIQT concern
Severity Score:3.0
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- CONTRAINDICATIONS
- Amitriptyline hydrochloride should not be given with cisapride due to the potential for increased QT interval and increased risk for arrhythmia.
- OVERDOSAGE
- Critical manifestations of overdose include: cardiac dysrhythmias, severe hypotension, convulsions, and CNS depression, including coma. Changes in the electrocardiogram particularly in QRS axis or width, are clinically significant indicators of tricyclic antidepressant toxicity. In addition, a rightward axis shift in the terminal QRS complex together with a prolonged QT interval and sinus tachycardia are specific and sensitive indicators of first generation tricyclic overdose. The absence of these findings is not exclusionary. Prolonged PR interval, ST-T wave changes, ventricular tachycardia and fibrillation may also occur.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
QT Prolongation
124
23968
Other ADRs
13587
38368000
Odds Ratio = 14.61
Drug Property Information
ATC Code(s):
- N06AA09 - amitriptyline hydrochloride
- N06AA - Non-selective monoamine reuptake inhibitors
- N06A - ANTIDEPRESSANTS
- N06 - PSYCHOANALEPTICS
- N - NERVOUS SYSTEM
Active Ingredient:AMITRIPTYLINE HYDROCHLORIDE
Active Ingredient UNII:26LUD4JO9K
Drugbank ID:DB00321
PubChem Compound:2160
CTD ID:D000639
PharmGKB:PA448385
CAS Number:50-48-6
Dosage Form(s):tablet, film coated
Route(s) Of Administrator:oral
Daily Dose:
- 75.0 mg/day N06AA09
Chemical Structure: 
SMILE Code:
CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
Reference
N/A
Disclaimer:
The content of this database of QT prolongation is intended for educational and scientific research purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment.
Any mention of commercial products is for clarification and not intended as endorsement.