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MELOXICAM
DIR Classification
Classification:Ambiguous
Severity Score:1.0
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- CLINICAL PHARMACOLOGY
- Pharmacodynamics
- Cardiac Electrophysiology
- The effect of ANJESO on QTc prolongation was evaluated in a randomized, double-blind, placebo-controlled crossover study in healthy subjects. A total of 48 subjects were administered intravenous meloxicam 30 mg, 120 mg, and 180 mg. In a study with demonstrated ability to detect small effects, the upper bound of the 90% confidence interval for the largest placebo-adjusted, baseline- corrected QTc based on Fridericia correction method (QTcF) was below 10 ms, the threshold for regulatory concern.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
QT Prolongation
5
24087
Other ADRs
15994
38365593
Odds Ratio = 0.498
Drug Property Information
ATC Code(s):
- M01AC06 - meloxicam
- M01AC - Oxicams
- M01A - "ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS"
- M01 - ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
- M - MUSCULO-SKELETAL SYSTEM
- N01BB59 - meloxicam
- N01BB - Amides
- N01B - "ANESTHETICS, LOCAL"
- N01 - ANESTHETICS
- N - NERVOUS SYSTEM
- M01AC56 - meloxicam
- M01AC - Oxicams
- M01A - "ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS"
- M01 - ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
- M - MUSCULO-SKELETAL SYSTEM
Active Ingredient:MELOXICAM
Active Ingredient UNII:VG2QF83CGL
Drugbank ID:DB00814
PubChem Compound:54677470
CTD ID:D000077239
PharmGKB:PA450353
CAS Number:71125-38-7
Dosage Form(s):injection
Route(s) Of Administrator:intravenous
Daily Dose:
- 15.0 mg/day M01AC06
Chemical Structure: 
SMILE Code:
CN1C(C(=O)NC2=NC=C(C)S2)=C(O)C2=C(C=CC=C2)S1(=O)=O
CN1C(C(=O)NC2=NC=C(C)S2)=C(O)C2=C(C=CC=C2)S1(=O)=O
Reference
N/A
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The content of this database of QT prolongation is intended for educational and scientific research purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment.
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