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HALOPERIDOL


DIR Classification


Classification:Most-DIQT concern
Severity Score:4.0

Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF

  • WARNINGS
  • Cardiovascular Effects
  • Cases of sudden death, QT-prolongation, and Torsades de Pointes have been reported in patients receiving haloperidol. Higher than recommended doses of any formulation of haloperidol appear to be associated with a higher risk of QT-prolongation and Torsades de Pointes. Although cases have been reported even in the absence of predisposing factors, particular caution is advised in treating patients with other QT-prolonging conditions (including electrolyte imbalance [particularly hypokalemia and hypomagnesemia], drugs known to prolong QT, underlying cardiac abnormalities, hypothyroidism, and familial long QT-syndrome).
  • ADVERSE REACTIONS
  • Cardiovascular Effects
  • Tachycardia, hypotension, and hypertension have been reported. QT prolongation and/or ventricular arrhythmias have also been reported, in addition to ECG pattern changes compatible with the polymorphous configuration of torsade de pointes, and may occur more frequently with high doses and in predisposed patients (see WARNINGS and PRECAUTIONS).
  • Cases of sudden and unexpected death have been reported in association with the administration of haloperidol. The nature of the evidence makes it impossible to determine definitively what role, if any, haloperidol played in the outcome of the reported cases. The possibility that haloperidol caused death cannot, of course, be excluded, but it is to be kept in mind that sudden and unexpected death may occur in psychotic patients when they go untreated or when they are treated with other antipsychotic drugs.

Postmarketing Surveillance

Contingency Table:

Current Drug
Other Drugs
QT Prolongation
231
23861
Other ADRs
31136
38350451

Odds Ratio = 11.925

Drug Property Information



ATC Code(s):
  • N05AD01 - haloperidol
    • N05AD - Butyrophenone derivatives
    • N05A - ANTIPSYCHOTICS
    • N05 - PSYCHOLEPTICS
    • N - NERVOUS SYSTEM
Active Ingredient:HALOPERIDOL
Active Ingredient UNII:J6292F8L3D
Drugbank ID:DB00502
PubChem Compound:3559
CTD ID:D006220
PharmGKB:PA449841
CAS Number:52-86-8
Dosage Form(s):tablet
Route(s) Of Administrator:oral
Daily Dose:
  • 8.0 mg/day N05AD01
Chemical Structure:
SMILE Code:
OC1(CCN(CCCC(=O)C2=CC=C(F)C=C2)CC1)C1=CC=C(Cl)C=C1

Reference

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70: Optimisation of embryonic and larval ECG measurement in zebrafish for quantifying the effect of QT prolonging drugs.

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71: Agreement between ICU clinicians and electrophysiology cardiologists on the decision to initiate a QTc-interval prolonging medication in critically ill patients with potential risk factors for torsade de pointes: a comparative, case-based evaluation.

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72: Drug-drug interactions contributing to QT prolongation in cardiac intensive care units.

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77: Improvement in QTc prolongation induced by zotepine following a switch to perospirone.

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78: Survey of methadone-drug interactions among patients of methadone maintenance treatment program in Taiwan.

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Subst Abuse Treat Prev Policy,2012 Mar 20;7:11. PMID: 22429858

79: The electro-mechanical window in anaesthetized guinea pigs: a new marker in screening for Torsade de Pointes risk.

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Br J Pharmacol,2012 May;166(2):689-701. PMID: 22122450

80: QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes.

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Dtsch Arztebl Int,2011 Oct;108(41):687-93. PMID: 22114630

81: Role of implantable cardioverter defibrillator therapy in patients with acquired long QT syndrome: a long-term follow-up.

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Europace,2012 Mar;14(3):396-401. PMID: 21979994

82: Differential changes in QTc duration during in-hospital haloperidol use.

[Blom Marieke T,Bardai Abdennasser,van Munster Barbara C,Nieuwland Mei-Ing,de Jong Hendrik,van Hoeijen Daniel A,Spanjaart Anne M,de Boer Anthonius,de Rooij Sophia E,Tan Hanno L]
PLoS One,2011;6(9):e23728. PMID: 21961030

83: Safety of antipsychotics in the setting of QTc prolongation: the utility of the JT index.

[Mukherji Emily H,Bauer Leah K,Leskov Ilya,Januzzi James Louis,Tanev Kaloyan S]
Am J Psychiatry,2011 Sep;168(9):990-1. PMID: 21890808

84: Comparative safety of antipsychotics in the WHO pharmacovigilance database: the haloperidol case.

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Int J Clin Pharm,2011 Oct;33(5):806-14. PMID: 21809143

85: Atypical antipsychotics for the treatment of ICU delirium.

[Gilchrist Neil A,Asoh Ifeoma,Greenberg Bruce]
J Intensive Care Med,Nov-Dec 2012;27(6):354-61. PMID: 21441282

86: Iloperidone for the treatment of schizophrenia.

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Drugs Today (Barc),2010 Aug;46(8):567-79. PMID: 20830317

87: Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.

[Cubeddu Luigi X]
Curr Cardiol Rev,2009 Aug;5(3):166-76. PMID: 20676275

88: Causes and management of drug-induced long QT syndrome.

[Ayad Ramy F,Assar Manish D,Simpson Leo,Garner John B,Schussler Jeffrey M]
Proc (Bayl Univ Med Cent),2010 Jul;23(3):250-5. PMID: 20671821

89: Effects of K openers on the QT prolongation induced by HERG-blocking drugs in guinea-pigs.

[Testai Lara,Cecchetti Violetta,Sabatini Stefano,Martelli Alma,Breschi Maria Cristina,Calderone Vincenzo]
J Pharm Pharmacol,2010 Jul;62(7):924-30. PMID: 20636881

90: Effects of high-dose ziprasidone and haloperidol on the QTc interval after intramuscular administration: a randomized, single-blind, parallel-group study in patients with schizophrenia or schizoaffective disorder.

[Miceli Jeffrey J,Tensfeldt Thomas G,Shiovitz Thomas,Anziano Richard J,O'Gorman Cedric,Harrigan Rachel H]
Clin Ther,2010 Mar;32(3):472-91. PMID: 20399985

91: The FDA extended warning for intravenous haloperidol and torsades de pointes: how should institutions respond?

[Meyer-Massetti Carla,Cheng Christine M,Sharpe Bradley A,Meier Christoph R,Guglielmo B Joseph]
J Hosp Med,2010 Apr;5(4):E8-16. PMID: 20394022

92: QT alterations in psychopharmacology: proven candidates and suspects.

[Alvarez Paulino Antonio,Pahissa Jaime]
Curr Drug Saf,2010 Jan;5(1):97-104. PMID: 20210726

93: Drug-induced QTc-interval prolongation in the intensive care unit: incidence and predictors.

[Ng Tien M H,Olsen Keith M,McCartan Megan A,Puumala Susan E,Speidel Katie M,Miller Melissa A,Sears Tom D]
J Pharm Pract,2010 Feb;23(1):19-24. PMID: 21507789

94: QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia.

[Ozeki Yuji,Fujii Kumiko,Kurimoto Naoki,Yamada Naoto,Okawa Masako,Aoki Takesuke,Takahashi Jun,Ishida Nobuya,Horie Minoru,Kunugi Hiroshi]
Prog Neuropsychopharmacol Biol Psychiatry,2010 Mar 17;34(2):401-5. PMID: 20079791

95: Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment.

[Fialova Katerina,Krizanova Olga,Jarkovsky Jiri,Novakova Marie]
Can J Physiol Pharmacol,2009 Dec;87(12):1019-27. PMID: 20029538

96: Proarrhythmic risk with antipsychotic and antidepressant drugs: implications in the elderly.

[Vieweg W Victor R,Wood Mark A,Fernandez Antony,Beatty-Brooks Mary,Hasnain Mehrul,Pandurangi Anand K]
Drugs Aging,2009;26(12):997-1012. PMID: 19929028

97: Efficacy and safety of quetiapine in critically ill patients with delirium: a prospective, multicenter, randomized, double-blind, placebo-controlled pilot study.

[Devlin John W,Roberts Russel J,Fong Jeffrey J,Skrobik Yoanna,Riker Richard R,Hill Nicholas S,Robbins Tracey,Garpestad Erik]
Crit Care Med,2010 Feb;38(2):419-27. PMID: 19915454

98: Modulation of haloperidol induced electrophysiological alterations on cardiac action potential by various risk factors and gender difference.

[Raghu K G,Singh Richa,Prathapan A,Yadav Govind Kumar]
Chem Biol Interact,2009 Aug 14;180(3):454-9. PMID: 19433077

99: Torsade de pointes following intravenous haloperidol administration in a patient with complete heart block.

[Ginwalla Mahazarin,Biblo Lee Arnold,Paydak Hakan]
WMJ,2009 Feb;108(1):48-50. PMID: 19326637

100: Low-dose haloperidol-associated QTc prolongation.

[Stepkovitch Khatuna,Heagle Bahn Christine,Gupta Reeta]
J Am Geriatr Soc,2008 Oct;56(10):1963-4. PMID: 19054204

101: Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients.

[Freeman Bradley D,Dixon David J,Coopersmith Craig M,Zehnbauer Barbara A,Buchman Timothy G]
Pharmacoepidemiol Drug Saf,2008 Oct;17(10):971-81. PMID: 18693297

102: An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia.

[Dhein Stefan,Perlitz Franziska,Mohr Friedrich-Wilhelm]
Naunyn Schmiedebergs Arch Pharmacol,2008 Dec;378(6):631-44. PMID: 18648775

103: Haloperidol plus ondansetron versus ondansetron alone for prophylaxis of postoperative nausea and vomiting.

[Grecu Loreta,Bittner Edward A,Kher Jay,Smith Sarah E,Rosow Carl E]
Anesth Analg,2008 May;106(5):1410-3, table of contents. PMID: 18420853

104: The prophylactic effect of haloperidol plus dexamethasone on postoperative nausea and vomiting in patients undergoing laparoscopically assisted vaginal hysterectomy.

[Chu Chin-Chen,Shieh Ja-Ping,Tzeng Jann-Inn,Chen Jen-Yin,Lee Yi,Ho Shung-Tai,Wang Jhi-Joung]
Anesth Analg,2008 May;106(5):1402-6, table of contents. PMID: 18420851

105: Asymptomatic QTc prolongation during coadministration of aripiprazole and haloperidol.

[Leo Roberto,Razzini Cinzia,Di Lorenzo Giorgio,Bianchi Francesco,Tesauro Manfredi,Zanasi Marco,Siracusano Alberto,Romeo Francesco]
J Clin Psychiatry,2008 Feb;69(2):327-8. PMID: 18363460

106: A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499.

[Chaves A A,Zingaro G J,Yordy M A,Bustard K A,O'Sullivan S,Galijatovic-Idrizbegovic A,Schuck H,Christian D B,Hoe C M,Briscoe R J]
J Pharmacol Toxicol Methods,Sep-Oct 2007;56(2):103-14. PMID: 17643323

107: Comparison of guinea-pig ventricular myocytes and dog Purkinje fibres for in vitro assessment of drug-induced delayed repolarization.

[Terrar Derek A,Wilson C M,Graham S G,Bryant S M,Heath B M]
J Pharmacol Toxicol Methods,Sep-Oct 2007;56(2):171-85. PMID: 17596973

108: State dependent dissociation of HERG channel inhibitors.

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Br J Pharmacol,2007 Aug;151(8):1368-76. PMID: 17592502

109: Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs.

[Kågström Jens,Sjögren Eva-Lena,Ericson Ann-Christin]
J Pharmacol Toxicol Methods,Sep-Oct 2007;56(2):186-93. PMID: 17582787

110: Sertindole: new drug. Another "atypical" neuroleptic; QT prolongation.


Prescrire Int,2007 Apr;16(88):59-62. PMID: 17458045

111: QT prolongation in guinea pigs for preliminary screening of torsadogenicity of drugs and drug-candidates. II.

[Testai L,Breschi M C,Martinotti E,Calderone V]
J Appl Toxicol,May-Jun 2007;27(3):270-5. PMID: 17265420

112: Accuracy of uncorrected versus corrected QT interval for prediction of torsade de pointes associated with intravenous haloperidol.

[Tisdale James E,Kovacs Richard,Mi Deming,McCabe George P,Cariera Beth L,Sharma Nagaraja,Rosman Howard]
Pharmacotherapy,2007 Feb;27(2):175-82. PMID: 17253907

113: Sertindole: efficacy and safety in schizophrenia.

[Lindström Eva,Levander Sten]
Expert Opin Pharmacother,2006 Sep;7(13):1825-34. PMID: 16925508

114: Combined effects of itraconazole and CYP2D6*10 genetic polymorphism on the pharmacokinetics and pharmacodynamics of haloperidol in healthy subjects.

[Park Ji-Young,Shon Ji-Hong,Kim Kyoung-Ah,Jung Hyun-Ju,Shim Joo-Cheol,Yoon Young-Ran,Cha In-June,Shin Jae-Gook]
J Clin Psychopharmacol,2006 Apr;26(2):135-42. PMID: 16633141

115: QT PRODACT: sensitivity and specificity of the canine telemetry assay for detecting drug-induced QT interval prolongation.

[Miyazaki Hiroyasu,Watanabe Hiroyuki,Kitayama Tetsuya,Nishida Masahiro,Nishi Yasuhiro,Sekiya Koji,Suganami Hideki,Yamamoto Keiji]
J Pharmacol Sci,2005;99(5):523-9. PMID: 16493192

116: QT PRODACT: in vivo QT assay with a conscious monkey for assessment of the potential for drug-induced QT interval prolongation.

[Ando Kentaro,Hombo Toshiyasu,Kanno Akihiro,Ikeda Hironobu,Imaizumi Masakazu,Shimizu Noritsugu,Sakamoto Kengo,Kitani Shin-ichi,Yamamoto Yoshinori,Hizume Shingo,Nakai Keiko,Kitayama Tetsuya,Yamamoto Keiji]
J Pharmacol Sci,2005;99(5):487-500. PMID: 16493189

117: QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals.

[Toyoshima Shigeki,Kanno Akihiro,Kitayama Tetsuya,Sekiya Koji,Nakai Keiko,Haruna Masao,Mino Terumasa,Miyazaki Hiroyasu,Yano Koji,Yamamoto Keiji]
J Pharmacol Sci,2005;99(5):459-71. PMID: 16493187

118: In vivo recording of adult zebrafish electrocardiogram and assessment of drug-induced QT prolongation.

[Milan David J,Jones Ian L,Ellinor Patrick T,MacRae Calum A]
Am J Physiol Heart Circ Physiol,2006 Jul;291(1):H269-73. PMID: 16489111

119: Assessment of drug-induced QT interval prolongation in conscious rabbits.

[Kijtawornrat A,Ozkanlar Y,Keene B W,Roche B M,Hamlin D M,Hamlin R L]
J Pharmacol Toxicol Methods,Mar-Apr 2006;53(2):168-73. PMID: 16290300

120: Aripiprazole: new drug. Just another neuroleptic.


Prescrire Int,2005 Oct;14(79):163-7. PMID: 16285069

121: Antipsychotic drugs and QT prolongation.

[Stöllberger Claudia,Huber Johannes O,Finsterer Josef]
Int Clin Psychopharmacol,2005 Sep;20(5):243-51. PMID: 16096514

122: A retrospective study of the safety of intramuscular ziprasidone in agitated elderly patients.

[Greco K Elizabeth,Tune Larry E,Brown Frank W,Van Horn William A]
J Clin Psychiatry,2005 Jul;66(7):928-9. PMID: 16013910

123: Excellent review of psychotropic drug-induced torsade de pointes.

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Acta Psychiatr Scand,2005 Jul;112(1):78; author reply 78-9. PMID: 15952952

124: QT interval prolongation related to psychoactive drug treatment: a comparison of monotherapy versus polytherapy.

[Sala Michela,Vicentini Alessandro,Brambilla Paolo,Montomoli Cristina,Jogia Jigar Rs,Caverzasi Eduardo,Bonzano Alberto,Piccinelli Marco,Barale Francesco,De Ferrari Gaetano M]
Ann Gen Psychiatry,2005 Jan 25;4(1):1. PMID: 15845138

125: Torsade de pointes induced by psychotropic drugs and the prevalence of its risk factors.

[Justo D,Prokhorov V,Heller K,Zeltser D]
Acta Psychiatr Scand,2005 Mar;111(3):171-6. PMID: 15701100

126: Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death.

[Titier Karine,Girodet Pierre-Olivier,Verdoux Hélène,Molimard Mathieu,Bégaud Bernard,Haverkamp Wilhelm,Lader Malcolm,Moore Nicholas]
Drug Saf,2005;28(1):35-51. PMID: 15649104

127: Intramuscular haloperidol or lorazepam and QT intervals in schizophrenia.

[Harvey Anne T,Flockhart David,Gorski J Christopher,Greenblatt David J,Burke Michael,Werder Steve,Preskorn Sheldon H]
J Clin Pharmacol,2004 Oct;44(10):1173-84. PMID: 15342619

128: QT analysis: a complex answer to a 'simple' problem.

[Li Lang,Desai Mehul,Desta Zeruesenay,Flockhart David]
Stat Med,2004 Sep 15;23(17):2625-43. PMID: 15316947

129: Determination of myocardium to plasma concentration ratios of five antipsychotic drugs: comparison with their ability to induce arrhythmia and sudden death in clinical practice.

[Titier Karine,Canal Mireille,Déridet Evelyne,Abouelfath Abdelilah,Gromb Sophie,Molimard Mathieu,Moore Nicholas]
Toxicol Appl Pharmacol,2004 Aug 15;199(1):52-60. PMID: 15289090

130: QT prolongation in anaesthetized guinea-pigs: an experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates.

[Testai L,Calderone V,Salvadori A,Breschi M C,Nieri P,Martinotti E]
J Appl Toxicol,May-Jun 2004;24(3):217-22. PMID: 15211616

131: Haloperidol in palliative care.

[Vella-Brincat Jane,Macleod A D]
Palliat Med,2004 Apr;18(3):195-201. PMID: 15198132

132: Prolonged cardiac repolarization after tacrolimus and haloperidol administration in the critically ill patient.

[Akers Wendell S,Flynn Jeremy D,Davis George A,Green Amy E,Winstead P Shane,Strobel Gunnar]
Pharmacotherapy,2004 Mar;24(3):404-8. PMID: 15040655

133: Dopamine partial agonists: a new class of antipsychotic.

[Lieberman Jeffrey A]
CNS Drugs,2004;18(4):251-67. PMID: 15015905

134: A randomized evaluation of the effects of six antipsychotic agents on QTc, in the absence and presence of metabolic inhibition.

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J Clin Psychopharmacol,2004 Feb;24(1):62-9. PMID: 14709949

135: QTc prolongation: possible association with risperidone and/or haloperidol.

[Nandagopal Jayasree J,Craig Jeffrey M,Lippmann Steven]
Psychosomatics,Nov-Dec 2003;44(6):521. PMID: 14597690

136: Torsade de pointes associated with the administration of intravenous haloperidol:a review of the literature and practical guidelines for use.

[Hassaballa Hesham A,Balk Robert A]
Expert Opin Drug Saf,2003 Nov;2(6):543-7. PMID: 14585064

137: QTc prolongation due to propranolol overdose.

[Farhangi Vida,Sansone Randy A]
Int J Psychiatry Med,2003;33(2):201-2. PMID: 12968835

138: Antipsychotic drugs and QT interval prolongation.

[Zareba Wojciech,Lin David A]
Psychiatr Q,Fall 2003;74(3):291-306. PMID: 12918603

139: Variability of heart rate correction methods for the QT interval.

[Desai Mehul,Li Lang,Desta Zeruesenay,Malik Marek,Flockhart David]
Br J Clin Pharmacol,2003 Jun;55(6):511-7. PMID: 12814443

140: Pharmacokinetics and QT interval pharmacodynamics of oral haloperidol in poor and extensive metabolizers of CYP2D6.

[Desai M,Tanus-Santos J E,Li L,Gorski J C,Arefayene M,Liu Y,Desta Z,Flockhart D A]
Pharmacogenomics J,2003;3(2):105-13. PMID: 12746736

141: Ziprasidone in the management of schizophrenia : the QT interval issue in context.

[Taylor David]
CNS Drugs,2003;17(6):423-30. PMID: 12697001

142: Management of the violent patient.

[Brice Jane H,Pirrallo Ronald G,Racht Edward,Zachariah Brian S,Krohmer Jon]
Prehosp Emerg Care,Jan-Mar 2003;7(1):48-55. PMID: 12540143

143: Torsade de pointes associated with the administration of intravenous haloperidol.

[Hassaballa Hesham A,Balk Robert A]
Am J Ther,Jan-Feb 2003;10(1):58-60. PMID: 12522522

144: The effects of the FDA warning on the use of droperidol by u.s. Emergency physicians.

[Richards John R,Weiss Steven J,Bretz Stephen W,Schneir Aaron B,Rinetti Dauna,Derlet Robert W]
Cal J Emerg Med,2003 Jan;4(1):3-9. PMID: 20852711

145: Investigation of the potential of clozapine to cause torsade de pointes.

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Adverse Drug React Toxicol Rev,2002;21(4):189-203. PMID: 12503253

146: Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability.

[Hondeghem Luc M,Hoffmann Peter]
J Cardiovasc Pharmacol,2003 Jan;41(1):14-24. PMID: 12500017

147: Aripiprazole.

[McGavin Jane K,Goa Karen L]
CNS Drugs,2002;16(11):779-86; discussion 787-8. PMID: 12383035

148: Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death.

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Am J Psychiatry,2001 Nov;158(11):1774-82. PMID: 11691681

149: Olanzapine: new preparation. Keep an eye on this neuroleptic.


Prescrire Int,1999 Oct;8(43):135-8. PMID: 11503836

150: The association between intravenous haloperidol and prolonged QT interval.

[Hatta K,Takahashi T,Nakamura H,Yamashiro H,Asukai N,Matsuzaki I,Yonezawa Y]
J Clin Psychopharmacol,2001 Jun;21(3):257-61. PMID: 11386487

151: Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part II: Pharmacological profile.

[Lande G,Demolombe S,Bammert A,Moorman A,Charpentier F,Escande D]
Cardiovasc Res,2001 May;50(2):328-34. PMID: 11334836

152: Analysis of the QTc interval during olanzapine treatment of patients with schizophrenia and related psychosis.

[Czekalla J,Beasley C M,Dellva M A,Berg P H,Grundy S]
J Clin Psychiatry,2001 Mar;62(3):191-8. PMID: 11305706

153: Familial and acquired long qt syndrome and the cardiac rapid delayed rectifier potassium current.

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Clin Exp Pharmacol Physiol,2000 Oct;27(10):753-66. PMID: 11022966

154: Drug interactions with cisapride: clinical implications.

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Clin Pharmacokinet,2000 Jul;39(1):49-75. PMID: 10926350

155: Effect of magnesium sulfate on the haloperidol-induced QT prolongation assessed in the canine in vivo model under the monitoring of monophasic action potential.

[Satoh Y,Sugiyama A,Tamura K,Hashimoto K]
Jpn Circ J,2000 Jun;64(6):445-51. PMID: 10875735

156: Torsades de pointes secondary to intravenous haloperidol after coronary bypass grafting surgery.

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Can J Anaesth,2000 Mar;47(3):251-4. PMID: 10730737

157: Olanzapine. Keep an eye on this neuroleptic.


Can Fam Physician,2000 Feb;46:322-6, 330-6. PMID: 10690489

158: Haloperidol-induced torsade de pointes.

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Ann Pharmacother,1999 Oct;33(10):1046-50. PMID: 10534216

159: The use of atypical antipsychotics in the management of schizophrenia.

[Campbell M,Young P I,Bateman D N,Smith J M,Thomas S H]
Br J Clin Pharmacol,1999 Jan;47(1):13-22. PMID: 10073734

160: Prolongation of QT interval in isolated feline hearts by antipsychotic drugs.

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J Clin Psychopharmacol,1998 Dec;18(6):477-81. PMID: 9864081

161: Torsade de pointes and low-dose oral haloperidol.

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Arch Intern Med,1997 Sep 22;157(17):2013-5. PMID: 9308514

162: The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes.

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Br J Pharmacol,1997 Mar;120(5):968-74. PMID: 9138706

163: Significantly higher plasma haloperidol level during cotreatment with carbamazepine may herald cardiac change.

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Clin Neuropharmacol,1996 Jun;19(3):267-70. PMID: 8726546

164: Use of haloperidol infusions to control delirium in critically ill adults.

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Ann Pharmacother,Jul-Aug 1995;29(7-8):690-3. PMID: 8520081

165: Torsade de pointes complicating the treatment of bleeding esophageal varices: association with neuroleptics, vasopressin, and electrolyte imbalance.

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Am J Gastroenterol,1995 May;90(5):822-4. PMID: 7733096

166: Torsade de pointes caused by high-dose intravenous haloperidol in cardiac patients.

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Clin Cardiol,1995 May;18(5):285-90. PMID: 7628136

167: Torsade de pointes associated with the use of intravenous haloperidol.

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Ann Intern Med,1993 Sep 1;119(5):391-4. PMID: 8338292

168: Life-threatening ventricular arrhythmia (torsades de pointes) after haloperidol overdose.

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Hum Exp Toxicol,1991 Jan;10(1):59-62. PMID: 1673626

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The content of this database of QT prolongation is intended for educational and scientific research purposes only. It is not intended as a substitute for professional medical advice, diagnosis or treatment.

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