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LITHIUM CARBONATE
DIR Classification
Classification:Ambiguous
Severity Score:1.0
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- WARNINGS AND PRECAUTIONS
- Lithium Toxicity
- Neurological signs of lithium toxicity range from mild neurological adverse reactions such as fine tremor, lightheadedness, lack of coordination, and weakness; to moderate manifestations like giddiness, apathy, drowsiness, hyperreflexia, muscle twitching, ataxia, blurred vision, tinnitus, and slurred speech; and severe manifestations such as clonus, confusion, seizure, coma, and death. In rare cases, neurological sequelae may persist despite discontinuing lithium treatment and may be associated with cerebellar atrophy. Cardiac manifestations involve electrocardiographic changes, such as prolonged QT interval, ST and T-wave changes and myocarditis. Renal manifestations include urine concentrating defect, nephrogenic diabetes insipidus, and renal failure. Respiratory manifestations include dyspnea, aspiration pneumonia, and respiratory failure. Gastrointestinal manifestations include nausea, vomiting, diarrhea, and bloating. No specific antidote for lithium poisoning is known [see Overdosage (10)].
- ADVERSE REACTIONS
- ECG Changes: reversible flattening, isoelectricity or rarely inversion of T-waves, prolongation of the QTc interval.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
QT Prolongation
59
24033
Other ADRs
16796
38364791
Odds Ratio = 5.608
Drug Property Information
ATC Code(s):
- N05AN01 - lithium carbonate
- N05AN - Lithium
- N05A - ANTIPSYCHOTICS
- N05 - PSYCHOLEPTICS
- N - NERVOUS SYSTEM
Active Ingredient:LITHIUM CARBONATE
Active Ingredient UNII:2BMD2GNA4V
Drugbank ID:DB14509
PubChem Compound:N/ADIR Classification
CTD ID:D016651
CAS Number:554-13-2
Dosage Form(s):capsule
Route(s) Of Administrator:oral
Daily Dose:
- 24mmol mg/day N05AN01
Chemical Structure: 
SMILE Code:
[Li+].[Li+].[O-]C([O-])=O
[Li+].[Li+].[O-]C([O-])=O
Reference
1: Sulpiride-associated torsade de pointes in a woman with bipolar disorder.
[Teng Po-Ren,Shen Thau-Yun,Lai Te-Jen]Psychiatry Clin Neurosci,2012 Apr;66(3):246. PMID: 22443253
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