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CARIPRAZINE
DIR Classification
Classification:Ambiguous
Severity Score:1.0
Description in Drug Labeling: View Full Labeling: SPL in DailyMed | PDF
- CLINICAL PHARMACOLOGY
- Pharmacodynamics
- Effect on QTc Interval
- At a dose three-times the maximum recommended dose, cariprazine does not prolong the QTc interval to clinically relevant extent.
Postmarketing Surveillance
Contingency Table:
Current Drug
Other Drugs
QT Prolongation
5
24087
Other ADRs
4805
38376782
Odds Ratio = 1.658
Drug Property Information
ATC Code(s):
- N05AX15 - cariprazine
- N05AX - Other antipsychotics
- N05A - ANTIPSYCHOTICS
- N05 - PSYCHOLEPTICS
- N - NERVOUS SYSTEM
Active Ingredient:CARIPRAZINE
Active Ingredient UNII:F6RJL8B278
Drugbank ID:DB06016
PubChem Compound:11154555
CTD ID:C533287
CAS Number:839712-12-8
Dosage Form(s):capsule, gelatin coated; kit
Route(s) Of Administrator:oral
Daily Dose:
- 3.0 mg/day N05AX15
Chemical Structure: 
SMILE Code:
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1
CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1
Reference
1: Safety and Tolerability of Cariprazine in Patients with Schizophrenia: A Pooled Analysis of Eight Phase II/III Studies.
[Barabássy Ágota,Sebe Barbara,Acsai Károly,Laszlovszky István,Szatmári Balázs,Earley Willie R,Németh György]Neuropsychiatr Dis Treat,2021 Apr 7;17:957-970. PMID: 33854317
2: [Brexpiprazole for treatment of schizophrenia: a critical literature study].
[Spoelstra S K,Baas C A J,Knegtering H]Tijdschr Psychiatr,2021;63(1):48-55. PMID: 33537974
3: Maximizing response to first-line antipsychotics in schizophrenia: a review focused on finding from meta-analysis.
[Smith Robert C,Leucht Stefan,Davis John M]Psychopharmacology (Berl),2019 Feb;236(2):545-559. PMID: 30506237
4: Clinical potential of cariprazine in the treatment of acute mania.
[Altınbaş Kürşat,Guloksuz Sinan,Oral Esat Timuçin]Psychiatr Danub,2013 Sep;25(3):207-13. PMID: 24048386
5: A new generation of antipsychotics: pharmacology and clinical utility of cariprazine in schizophrenia.
[Caccia Silvio,Invernizzi Roberto William,Nobili Alessandro,Pasina Luca]Ther Clin Risk Manag,2013;9:319-28. PMID: 23966785
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